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Sinemet, Sinemet-CR (Carbidopa, Levodopa)Carbidopa and Levodopa (trade names include Sinemet; Apo-Levocarb; Co-Careldopa; Sinemet-CR; Dopadura-C; Dopicar; Sinemet-LP; Duodopa; Half Sinemet; Kardopal; Levocarb; Sinemet Plus; Levodopa Comp.; Syndopa; Levomed; Nacom; Nakom; Sinemet Retard; Syndopa Plus; Tidomet) is a combined antiparkinson drug from dopa derivatives (Levodopa) and decarboxylase inhibitors (Carbidopa) pharmacological groups. This medication is used for the treatment of Parkinson's disease, its symptoms and conditions, including postencephalitic parkinsonism, idiopathic Parkinson's disease, symptomatic parkinsonism, muscle stiffness, tremors, spasms, poor muscle control; to treat Parkinson symptoms caused by carbon monoxide poisoning or manganese intoxication. It is also prescribed for the therapy of dopamine-responsive dystonia (DRD), restless legs syndrome (RLS), amblyopia.
Symptoms of Parkinson's disease may be caused by low levels of chemical called dopamine in the brain. Levodopa works by converting to dopamine in the brain. Carbidopa helps prevent the breakdown of levodopa before it can reach the brain and take effect.

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  • Sinemet (Carbidopa plus Levodopa) 10/100 mg tablets
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    There is an additional general information about Carbidopa/Levodopa (Sinemet, Sinemet-CR):


    Medical and pharmaceutical categories for levodopa plus carbidopa:

  • Antiparkinsonian drugs
  • Dopamine precursors
  • Central nervous system agents
  • Combinations of dopa derivatives with decarboxylase inhibitors
  • Combined medications for the treatment of Parkinson's disease
  • Medicines to treat parkinsonism
  • Muscle relaxants


    The Anatomical Therapeutic Chemical (ATC) classification system carbidopa with levodopa codes:

  • N - Nervous system
  • N04 - Anti-Parkinson drugs
  • N04B - Dopaminergic agents
  • N04BA - Dopa and dopa derivatives
  • N04BA02 - Levodopa and decarboxylase inhibitor


    Levodopa and Carbidopa in The International Statistical Classification of Diseases and Related Health Problems (ICD-10, World Health Organization) codes:

  • Parkinson's disease - G20
  • Secondary parkinsonism - G21
  • Parkinsonism in diseases classified elsewhere - G22


    Pregnancy categories for Carbidopa/Levodopa (Sinemet-CR, Sinemet):

  • B3 - Australia
  • C - United States (Risk cannot be ruled out)


    Salts and other levodopa with carbidopa forms used as active pharmaceutical ingredients (API):

  • Carbidopa Base with Levodopa Base
  • Carbidopa Anhydrous with Levodopa Base
  • Carbidopa Monohydrate with Levodopa Base


    Synonyms of carbidopa and levodopa, international and chemical names:

  • Carbidopa/L-DOPA
  • Co-Careldopa
  • L-DOPA/Karbidopa
  • Karbidopa/Levodopa
  • Levocarb
  • Levodopa e Carbidopa
  • Levodopa en carbidopa
  • Levodopa et Carbidopa
  • Levodopa ja Carbidopa
  • Levodopa och Karbidopa
  • Levodopa og Carbidopa
  • Levodopa und Carbidopa
  • Levodopa y Carbidopa
  • Levodopa/Karbidopa
  • Lewodopa/Karbidopa


    Best known carbidopa with levodopa brands, generics and trade names in various countries:

  • Apo-Levocarb - Apotex; Hind Wing; Pharmaforte
  • Atamet - Elan Pharmaceuticals
  • Carbidopa; Levodopa - Accord Healthcare; Actavis; Hexal; Mylan; Ratiopharm; Sandoz; Teva
  • Carbidopa; Levodopa CR - Sandoz
  • Carbilev - Ranbaxy; Aspen
  • Co-Careldopa - Teva
  • Credanil - Remedica; Goldplus Universal
  • Cronomet - Merck
  • Dopadura-C - Merck
  • Dopicar - Teva; Merck
  • Duodopa - Solvay; Abbott; AbbVie; Neopharma, Sweden; Zuellig Pharma
  • Half Sinemet - Bristol-Myers Squibb; United Drug
  • Kardopal - Orion Pharma
  • LCD - Intas Pharmaceuticals
  • Lebocar - Pfizer
  • Levobeta-C - Betapharm Arzneimittel
  • Levocar - Sandoz
  • Levocarb - Teva; Biolab Sanus Farmaceutica
  • Levocarb-CR - AA Pharma
  • Levocomp - Hexal
  • Levodopa Comp. - CT-Arzneimittel; Ratiopharm
  • Levodopa Comp. C - Stada
  • Levomed - Medochemie; Komedic; Medline; Star Medical Supplies
  • Nacom - Bristol-Myers Squibb
  • Nacom Retard - Bristol-Myers Squibb
  • Nakom - Sandoz; Lek; Merck
  • Nakom Mite - Sandoz
  • Parcopa - Schwarz Pharma
  • Parkidopa - Cristalia Produtos Quimicos Farmaceuticos
  • Parkinel - Bago Laboratorios
  • Sinemet - Merck
  • Sinemet Plus - Merck; Bristol-Myers Squibb
  • Sinemet Retard - Merck; Bristol-Myers Squibb
  • Sinemet-CR - Merck
  • Sinemet-LP - Merck; Bristol-Myers Squibb
  • Syndopa - Sun Pharmaceutical Industries
  • Syndopa Plus - Sun Pharmaceutical Industries
  • Syndopa-CR - Sun Pharmaceutical Industries; Pharmaland
  • Tidomet - Torrent Pharmaceuticals; Kaspa Pharmaceutical Thailand; Metro Drug Distribution


    Some other medications in Sinemet and Sinemet-CR (Carbidopa; Levodopa) pharmacological classes:

  • Almirid (Dihydroergocryptine Mesylate)
  • APO-Go (Apomorphine)
  • Aricept (Donepezil)
  • Artane (Trihexyphenidyl)
  • Dopergin (Lisuride)
  • Dostinex (Cabergoline)
  • Eldepryl (Selegiline)
  • Ethylevodopa (Etilevodopa)
  • Exelon (Rivastigmine)
  • Glucophage (Metformin)
  • Kemadrin (Procyclidine)
  • Levomet (Melevodopa)
  • Liserdol (Metergoline)
  • Mirapex (Pramipexole)
  • Namenda (Memantine)
  • Neupro (Rotigotine)
  • Norprolac (Quinagolide)
  • Parlodel (Bromocriptine)
  • Permax (Pergolide)
  • Reminyl (Galantamine)
  • Requip (Ropinirole)
  • Stalevo (Carbidopa; Levodopa; Entacapone)
  • Symmetrel (Amantadine)
  • Teluron (Terguride)
  • Trivastal (Piribedil)


    Here is a list of some medications containing "Carbidopa" and "Levodopa" as main active pharmaceutical ingredients (APIs) of carbidopa/levodopa drugs, their trade names, available forms, doses and also pharmaceutical companies - manufacturers, distributors and suppliers, researchers and developers:

    Trade name of the drug Pharmaceutical forms and doses Companies
    Sinemet
  • Tablets; Oral; Carbidopa 10 mg; Levodopa 100 mg
  • Tablets; Oral; Carbidopa 12.5 mg; Levodopa 50 mg
  • Tablets; Oral; Carbidopa 25 mg; Levodopa 100 mg
  • Tablets; Oral; Carbidopa 25 mg; Levodopa 250 mg
  • Tablets, Prolonged Release; Oral; Carbidopa 25 mg; Levodopa 100 mg
  • Tablets, Prolonged Release; Oral; Carbidopa 50 mg; Levodopa 200 mg
  • Merck
  • Algorithm
  • Bristol-Myers Squibb
  • Chandra Bhagat Pharma
  • DKSH
  • Dr. Fisher Farma
  • DuPont
  • Eureco-Pharma
  • Euro Registratie
  • Four Star
  • Institute of Pharmaceutical Research and Technology
  • Invida
  • M & H Manufacturing
  • Medcor Pharmaceuticals
  • Menarini
  • Mylan
  • OBS Healthcare
  • Orifarm
  • P & D Pharmaceuticals
  • Ramco Pharm
  • United Drug
  • Vianex
  • Zuellig Pharma
  • Sinemet-CR
  • Tablets, Controlled Release; Oral; Carbidopa 25 mg; Levodopa 100 mg
  • Tablets, Controlled Release; Oral; Carbidopa 50 mg; Levodopa 200 mg
  • Merck
  • Bristol-Myers Squibb
  • DKSH
  • Dr. Fisher Farma
  • Euro Registratie
  • Four Star
  • Institute of Pharmaceutical Research and Technology
  • Invida
  • Menarini
  • Mylan
  • Sofeco
  • Zuellig Pharma
  • Syndopa
  • Tablets; Oral; Carbidopa 10 mg; Levodopa 100 mg
  • Tablets; Oral; Carbidopa 25 mg; Levodopa 100 mg
  • Sun Pharmaceutical Industries
  • Pharmaland
  • Sin Phyu Kyun Company


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